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How does Synthroid work and what pharmaceutical group does it belong to?

Levothyroxin (L-thyroxin) is a synthetic hormone of thyroid gland; left-rotating isomer of thyroxine (T4); Synthroid is a medication that compensates the deficiency of thyroid gland hormones. Levothyroxine sodium is identical in respect to pharmacological action to natural hormone T4. After biotransformation in the organism into liothyronine and entering body cells, it exerts regulating action on development, growth of the organism and metabolism. In low doses Levothyroxine exerts anabolic action. In recommended doses the medication stimulates growth and development, increases the demand of tissue in oxygen, activates proteins, carbohydrate and lipid metabolism.

Which conditions are treated with Synthroid?

  • Hypothyroidism (except transient hypothyroidism during the recovery phase of subacute thyroiditis)
  • Euthyroid goiter
  • Diagnostics of thyroid suppression test
  • Thyroid cancer (after surgery)
  • Graves' disease

Patients with low levels of TSH should not use Synthroid. The medication is not intended to reduce weight in overweight or obese patients.

What should a patient know before using Synthroid?

The Synthroid should not be used in cases of:

  • Known hypersensitivity to any of the drug ingredients
  • Thyrotoxicosis
  • Pituitary insufficiency
  • Adrenal cortex insufficiency
  • Myocardial infarction (heart attack)
  • Acute myocarditis
  • Acute pancreatitis
  • Known hypersensitivity to any of medication ingredients

The medication should be used with caution in:

  • Coronary heart diseases (atherosclerosis, stenocardia, heart attack in anamnesis)
  • High blood pressure
  • Arrhythmias
  • Diabetes
  • Hypothyroidism
  • Malabsorption syndrome
  • Osteoporosis

Make sure to let your doctor know if you are pregnant, planning to become pregnant or breastfeeding.

Which adverse effects may manifest when using the medication?

Possible side effects of Synthroid include:

  • Swelling of the lips, mouth or throat
  • Itching
  • Hives
  • Skin rash
  • Shortness of breath

High doses of Synthroid may cause: insomnia, increased bones fragility, anxiety, high blood pressure, diarrhea, seizures, hair loss, fever, heart palpitations, emotional changes, muscle weakness

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Synthroid?

The drug is affected by the following:

  • Antacids
  • Antidepressants
  • Anti-diabetic drugs
  • Calcium containing
  • Estrogens
  • Cardiac glycosides (digoxin)
  • Iron
  • Weight loss pills (Orlistat)
  • Seizure drugs
  • Antic
  • Xantines
  • Stomach medications (sucralfate)

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient: Synthroid is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.